منابع مشابه
Autoinflammatory syndromes.
There has been an expansion of the autoinflammatory syndromes due to the discovery of new diseases related to mutations in genes regulating the innate immune system and the knowledge gained from these diseases as applied to more common nongenetic inflammatory conditions. Autoinflammatory syndromes are characterized by unprovoked (or triggered by minor events) recurrent episodes of systemic infl...
متن کاملPediatric hereditary autoinflammatory syndromes.
OBJECTIVE To describe the most prevalent pediatric hereditary autoinflammatory syndromes. SOURCES A review of the literature including relevant references from the PubMed and SciELO was carried out using the keywords autoinflammatory syndromes and child. SUMMARY OF THE FINDINGS The hereditary autoinflammatory syndromes are caused by monogenic defects of innate immunity and are classified as...
متن کاملAmyloidosis in autoinflammatory syndromes.
AA amyloidosis may still dramatically impact on the outcome of patients with autoinflammatory diseases, particularly when diagnosis is delayed. Clinicians should maintain a high level of attention to identify early this severe complication. Initial signs mostly reflect kidney damage, with proteinuria, with or without renal failure, being the more frequent presenting feature. If SAA levels are n...
متن کاملBiologic drugs in autoinflammatory syndromes.
PURPOSE OF THE REVIEW Inherited autoinflammatory syndromes are conditions caused by mutations of proteins playing a pivotal role in the regulation of the innate immunity leading to an uncontrolled inflammation. The understanding of the molecular pathways involved in these disorders has shed a new light on the pattern of activation and maintenance of the inflammatory response and disclosed new m...
متن کاملAutoinflammatory syndromes: diagnosis and management
During the last decades the description of autoinflammatory syndromes induced great interest among the scientific community. Mainly rheumatologists, immunologists and pediatricians are involved in the discovery of etiopathogenesis of these syndromes and in the recognition of affected patients. In this paper we will discuss the most important clues of monogenic and non-genetic inflammatory syndr...
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ژورنال
عنوان ژورنال: Dermatologic Clinics
سال: 2013
ISSN: 0733-8635
DOI: 10.1016/j.det.2013.05.001